Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Grb2tm2Paw
Name:	growth factor receptor bound protein 2; targeted mutation 2, Tony Pawson
MGI ID:	MGI:2677457
Synonyms:	E89K
Gene:	Grb2  Location: Chr11:115534871-115599423 bp, - strand  Genetic Position: Chr11, 80.91 cM
Alliance:	Grb2tm2Paw page

Germline Transmission:	Earliest citation of germline transmission: J:69138
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Hypomorph) Mutations:    Insertion, Single point mutation   Mutation details: A G-to-A mutation was introduced into codon 89 to alter this residue in the corresponding protein from a glutamate to a lysine through homologous recombination. A loxP-flanked neomycin selection cassette also introduced into intron 2 was deleted by cre-mediated recombination, resulting in a single loxP site remaining in the intron. This allele expresses a mutant protein and is thought to be hypomorphic. (J:69138)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Grb2 Mutation:	42 strains or lines available

Original:	J:69138 Saxton TM, et al., Gene dosage-dependent functions for phosphotyrosine-Grb2 signaling during mammalian tissue morphogenesis. Curr Biol. 2001 May 1;11(9):662-70
All:	2 reference(s)