Tg(KRT5-E2F1)1Dgj
Transgene Detail
|
|
| Symbol: |
Tg(KRT5-E2F1)1Dgj |
| Name: |
transgene insertion 1, David G Johnson |
| MGI ID: |
MGI:2384615 |
| Synonyms: |
1.0 |
| Transgene: |
Tg(KRT5-E2F1)1Dgj Location: unknown
|
| Alliance: |
Tg(KRT5-E2F1)1Dgj page
|
|
| Strain of Origin: |
(C57BL/6 x SJL/J)F2
|
|
| Transgene Type: |
|
Transgenic (Humanized sequence, Inserted expressed sequence) |
| Mutation: |
|
Insertion
|
| |
|
Tg(KRT5-E2F1)1Dgj expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
E2F1 (1869) |
|
|
|
| |
|
Tg(KRT5-E2F1)1Dgj expression driven by
1 gene
Transgene expression driven by:
| Organism |
Driver Gene |
Note |
| cattle |
KRT5 (281268) |
|
|
| |
|
Mutation details: Human E2F1 cDNA was adjoined to the bovine keratin 5 promoter, active in the basal cell compartment of stratified squamous epithelia. Expression of the human transgene was detected in basal keratinocytes by Northern blot analysis. Western blot analysis showed that the level of transgenic protein was 80 fold greater than that of the endogenous protein.
(J:46535)
|
|
|
|
|
| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
|
| Original: |
J:46535 Pierce AM, et al., Deregulated expression of E2F1 induces hyperplasia and cooperates with ras in skin tumor development. Oncogene. 1998 Mar 12;16(10):1267-76 |
| All: |
2 reference(s) |
|
Analysis Tools
