Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Nod1tm1Inoh
Name:	nucleotide-binding oligomerization domain containing 1; targeted mutation 1, Naohiro Inohara
MGI ID:	MGI:2674231
Synonyms:	Nod1-
Gene:	Nod1  Location: Chr6:54900934-54949597 bp, - strand  Genetic Position: Chr6, 27.22 cM
Alliance:	Nod1tm1Inoh page

Germline Transmission:	Earliest citation of germline transmission: J:85240
Parent Cell Line:	E14K (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 1 and 2 were replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region encoded the CARD domain which is essential for Ripk2 binding and Nfkb1 activation. Transcript was undetected by RT-PCR analysis of cells obtained from homozygous mutant mice. (J:85240)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nod1 Mutation:	125 strains or lines available

Original:	J:85240 Chamaillard M, et al., An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid. Nat Immunol. 2003 Jul;4(7):702-7
All:	43 reference(s)