Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Hint1tm1Ibw
Name:	histidine triad nucleotide binding protein 1; targeted mutation 1, I Bernard Weinstein
MGI ID:	MGI:2674018
Synonyms:	PKCI-
Gene:	Hint1  Location: Chr11:54757209-54761327 bp, + strand  Genetic Position: Chr11, 32.13 cM
Alliance:	Hint1tm1Ibw page

Germline Transmission:	Earliest citation of germline transmission: J:84504
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A 1.6 kb genomic fragment was replaced with a neomycin selection cassette inserted via homologous recombination. Normal protein was undetected by Western blot analysis of various organs obtained from homozygous mutant mice. (J:84504)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

List all tumor models in MMHCdb carrying Hint1tm1Ibw

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Hint1 Mutation:	24 strains or lines available

Original:	J:84504 Su T, et al., Deletion of histidine triad nucleotide-binding protein 1/PKC-interacting protein in mice enhances cell growth and carcinogenesis. Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7824-9
All:	17 reference(s)