Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pou3f3tm1Tno
Name:	POU domain, class 3, transcription factor 3; targeted mutation 1, Tetsuo Noda
MGI ID:	MGI:2673387
Synonyms:	Brn-1-
Gene:	Pou3f3  Location: Chr1:42734928-42739370 bp, + strand  Genetic Position: Chr1, 21.21 cM
Alliance:	Pou3f3tm1Tno page

Germline Transmission:	Earliest citation of germline transmission: J:84756
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: 70% (1.2 kb) of the endogenous coding region was replaced with a neo cassette. Gene product was undetected by Western blot analysis and electrophoresis mobility shift assay of homozygous mutant kidney and brain extracts, respectively. (J:84756)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pou3f3 Mutation:	10 strains or lines available

Original:	J:84756 Nakai S, et al., Crucial roles of Brn1 in distal tubule formation and function in mouse kidney. Development. 2003 Oct;130(19):4751-9
All:	4 reference(s)