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Pctptm1Bor
Targeted Allele Detail
Summary
Symbol: Pctptm1Bor
Name: phosphatidylcholine transfer protein; targeted mutation 1, Piet Borst
MGI ID: MGI:2673156
Synonyms: Pc-tp -, Pctp-
Gene: Pctp  Location: Chr11:89873491-89893720 bp, - strand  Genetic Position: Chr11, 54.7 cM
Alliance: Pctptm1Bor page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:57946
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin selection gene replaced exons C and D by homologous recombination. Western blot analysis demonstrated that no detectable protein product was made in the cytosol of cells derived from homozygous mice. (J:57946)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pctp Mutation:  15 strains or lines available
References
Original:  J:57946 van Helvoort A, et al., Mice without phosphatidylcholine transfer protein have no defects in the secretion of phosphatidylcholine into bile or into lung airspaces. Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11501-6
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory