Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Bcl2l1tm1Cant
Name:	BCL2-like 1; targeted mutation 1, Harvey Cantor
MGI ID:	MGI:2672833
Synonyms:	Bcl-xgamma-
Gene:	Bcl2l1  Location: Chr2:152622588-152673648 bp, - strand  Genetic Position: Chr2, 75.41 cM, cytoband H1
Alliance:	Bcl2l1tm1Cant page

Germline Transmission:	Earliest citation of germline transmission: J:77507
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: Exon 4 which encodes the carboxy terminal of the gamma isoform was replaced with a single loxP site after a floxed neomycin selection cassette was excised via cre mediated recombination. RT-PCR analysis of homozygous mutant T cells identified transcript encoding the L isoform in the absence of transcript encoding the gamma isoform. (J:77507)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bcl2l1 Mutation:	104 strains or lines available

Original:	J:77507 Ye Q, et al., T cell costimulation through CD28 depends on induction of the Bcl-xgamma isoform: analysis of Bcl-xgamma-deficient mice. J Exp Med. 2002 Jul 1;196(1):87-95
All:	1 reference(s)