Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Hnf1btm3Mya
Name:	HNF1 homeobox B; targeted mutation 3, Moshe Yaniv
MGI ID:	MGI:2670936
Synonyms:	Hnf1betaflox
Gene:	Hnf1b  Location: Chr11:83741035-83796743 bp, + strand  Genetic Position: Chr11, 51.23 cM
Alliance:	Hnf1btm3Mya page

Germline Transmission:	Earliest citation of germline transmission: J:75935
Parent Cell Line:	CK35 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A floxed neomycin selection cassette and an additional loxP site were inserted at the endogenous locus by homologous recombination. The neomycin selection cassette was deleted in ES cells by transient expression of Cre recombinase, resulting in loxP sites flanking the promoter region, the transcription initiation site, and exon 1 in the final allele. (J:75935)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	20 assay results
In Structures Affected by this Mutation:	8 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hnf1b Mutation:	16 strains or lines available

Original:	J:75935 Coffinier C, et al., Bile system morphogenesis defects and liver dysfunction upon targeted deletion of HNF1beta. Development. 2002 Apr;129(8):1829-38
All:	21 reference(s)