Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Prdx1tm1Rave
Name:	peroxiredoxin 1; targeted mutation 1, Richard A Van Etten
MGI ID:	MGI:2670538
Synonyms:	Prdx1-
Gene:	Prdx1  Location: Chr4:116542796-116557196 bp, + strand  Genetic Position: Chr4, 53.28 cM
Alliance:	Prdx1tm1Rave page

Germline Transmission:	Earliest citation of germline transmission: J:84677
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 3 was disrupted by the insertion of a transposon containing a PGK-neo cassette inserted by homologous recombination. (J:84677)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

List all tumor models in MMHCdb carrying Prdx1tm1Rave

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Prdx1 Mutation:	37 strains or lines available

Original:	J:84677 Neumann CA, et al., Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression. Nature. 2003 Jul 31;424(6948):561-5
All:	8 reference(s)