Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gpamtm1Rcol
Name:	glycerol-3-phosphate acyltransferase, mitochondrial; targeted mutation 1, Rosalind Coleman
MGI ID:	MGI:2669956
Synonyms:	Gpat1-, mtGPAT-
Gene:	Gpam  Location: Chr19:55056067-55115666 bp, - strand  Genetic Position: Chr19, 50.81 cM
Alliance:	Gpamtm1Rcol page

Germline Transmission:	Earliest citation of germline transmission: J:84541
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A 0.5 kb genomic fragment encoding 62 amino acids including those that make up homology regions II and III was replaced with a neo cassette inserted by homologous recombination. Transcript was undetected by Northern blot analysis of homozygous mutant liver tissue. Activity assays indicated a near comlpete ablation of endogenous activity and showed that the activity of the microsomal isoform was unperturbed. (J:84541)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gpam Mutation:	52 strains or lines available

Original:	J:84541 Hammond LE, et al., Mitochondrial glycerol-3-phosphate acyltransferase-deficient mice have reduced weight and liver triacylglycerol content and altered glycerolipid fatty acid composition. Mol Cell Biol. 2002 Dec;22(23):8204-14
All:	14 reference(s)