Summary | Mutation origin | Mutation description | Recombinase activity | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Gt(ROSA)26Sortm1(cre/ERT)Nat
Name:	gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Jeremy Nathans
MGI ID:	MGI:2669525
Synonyms:	CreERT1, Gt(ROSA)26Sortm1(cre/Esr1)Nat, R26CreER, R26ERCre, R26RNatCre
Gene:	Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance:	Gt(ROSA)26Sortm1(cre/ERT)Nat page

Germline Transmission:	Earliest citation of germline transmission: J:84747
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Gt(ROSA)26Sortm1(cre/ERT)Nat expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Gt(ROSA)26Sor (MGI:104735)   Mutation details: A cDNA fragment encoding a fusion protein comprised of cre recombinase and the ligand binding domain of Esr1 was inserted at the endogenous locus via homologous recombination. The initiator methionine was placed in an optimal translational context, allowing for near ubiquitous expression via the endogenous promoter. Activation of cre recombinase activity is dependent on the administration of 4-HO-tamoxifen. (J:84747)

Activity:	Tissue activity of this recombinase allele
Driver:	Gt(ROSA)26Sor (mouse) Summary of all recombinase alleles driven by Gt(ROSA)26Sor. Comparative matrix view of recombinase activities Alliance mouse Gt(ROSA)26Sor gene page

View phenotypes and curated references for all genotypes (concatenated display).

List all tumor models in MMHCdb carrying Gt(ROSA)26Sortm1(cre/ERT)Nat

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:	942 strains or lines available

Original:	J:84747 Badea TC, et al., A noninvasive genetic/pharmacologic strategy for visualizing cell morphology and clonal relationships in the mouse. J Neurosci. 2003 Mar 15;23(6):2314-22
All:	188 reference(s)