Summary | Mutation origin | Mutation description | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Serpini1tm1Dpw
Name:	serine (or cysteine) peptidase inhibitor, clade I, member 1; targeted mutation 1, David Paul Wolfer
MGI ID:	MGI:2668495
Synonyms:	Ns -
Gene:	Serpini1  Location: Chr3:75464800-75549830 bp, + strand  Genetic Position: Chr3, 33.76 cM
Alliance:	Serpini1tm1Dpw page

Germline Transmission:	Earliest citation of germline transmission: J:84427
Parent Cell Line:	GS1 (ES Cell)
Strain of Origin:	129/Sv

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A neo cassette was inserted into exon 2. Western blot analysis demonstrated the absence of gene product in homozygotes. (J:84427)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Serpini1 Mutation:	29 strains or lines available

Original:	J:84427 Madani R, et al., Impaired explorative behavior and neophobia in genetically modified mice lacking or overexpressing the extracellular serine protease inhibitor neuroserpin. Mol Cell Neurosci. 2003 Jul;23(3):473-94
All:	6 reference(s)