Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Ilktm1Star
Name:	integrin linked kinase; targeted mutation 1, Rene St-Arnaud
MGI ID:	MGI:2668459
Synonyms:	ILKfl, ILKflox, ILK(lox), ilkloxP
Gene:	Ilk  Location: Chr7:105385799-105392132 bp, + strand  Genetic Position: Chr7, 55.97 cM, cytoband E1
Alliance:	Ilktm1Star page

Germline Transmission:	Earliest citation of germline transmission: J:84273
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: LoxP sites were inserted downstream of exon 4 and exon 12 (along with a neomycin resistance gene cassette). (J:84273)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	26 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	18 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ilk Mutation:	18 strains or lines available

Original:	J:84273 Terpstra L, et al., Reduced chondrocyte proliferation and chondrodysplasia in mice lacking the integrin-linked kinase in chondrocytes. J Cell Biol. 2003 Jul 7;162(1):139-48
All:	60 reference(s)