Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Grik5tm1Cont
Name:	glutamate receptor, ionotropic, kainate 5 (gamma 2); targeted mutation 1, Anis Contractor
MGI ID:	MGI:2668206
Synonyms:	KA2-
Gene:	Grik5  Location: Chr7:24709274-24771771 bp, - strand  Genetic Position: Chr7, 13.73 cM
Alliance:	Grik5tm1Cont page

Germline Transmission:	Earliest citation of germline transmission: J:81742
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S/SvEv

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Sequence encompassing two full exons and a portion of a third, collectively encoding membrane domains I and II, were replaced with a neomycin selection cassette inserted by homologous recombination. Normal protein was undetected by immunohistochemical analysis of homozygous mutant hippocampal sections. (J:81742)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Grik5 Mutation:	50 strains or lines available

Original:	J:81742 Contractor A, et al., Loss of kainate receptor-mediated heterosynaptic facilitation of mossy-fiber synapses in KA2-/- mice. J Neurosci. 2003 Jan 15;23(2):422-9
All:	13 reference(s)