Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	H1f2tm2Ais
Name:	H1.2 linker histone, cluster member; targeted mutation 2, Arthur I Skoutchi
MGI ID:	MGI:2665852
Synonyms:	H1c-
Gene:	H1f2  Location: Chr13:23922790-23923514 bp, + strand  Genetic Position: Chr13, 9.9 cM, cytoband A2-A3
Alliance:	H1f2tm2Ais page

Germline Transmission:	Earliest citation of germline transmission: J:83954
Parent Cell Line:	WW6 (ES Cell)
Strain of Origin:	STOCK 129/Sv and C57BL/6J and SJL

Allele Type:    Targeted (Null/knockout) Mutation:    Disruption caused by insertion of vector   Mutation details: Most of the coding region, including the start site was replaced with a PGK-Hygro cassette. Lack of gene product was confirmed by reverse phase HPLC. (J:83954)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

2 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any H1f2 Mutation:	16 strains or lines available

Original:	J:83954 Fan Y, et al., H1 linker histones are essential for mouse development and affect nucleosome spacing in vivo. Mol Cell Biol. 2003 Jul;23(13):4559-72
All:	3 reference(s)