Tg(TAG-Tcra,TAG-Tcrb)2Dh
Transgene Detail
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| Symbol: |
Tg(TAG-Tcra,TAG-Tcrb)2Dh |
| Name: |
transgene insertion 2, Douglas Hanahan |
| MGI ID: |
MGI:2449061 |
| Synonyms: |
Tag-TCR2 |
| Transgene: |
Tg(TAG-Tcra,TAG-Tcrb)2Dh Location: unknown
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| Alliance: |
Tg(TAG-Tcra,TAG-Tcrb)2Dh page
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(TAG-Tcra,TAG-Tcrb)2Dh expresses
2 genes
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Mutation details: Two transgene constructs were used in the generation of this allele. One construct consists of a Tcra sequence encoding the Valpha2JalphaMT1-27 rearrangement, 6 kb of 5' flanking sequence, 3.8 kb of 3' flanking sequence, and a neomycin resistance gene. The other construct consists of a Tcrb sequence encoding the Vbeta8.3DJbeta2.4 rearrangement, 5.1 kb of 5' flanking sequence, 0.4 kb of 3' flanking sequence, and a neomycin resistance gene. This transgenic line carries multiple copies of both Tcra and Tcrb constructs cointegrated at one locus.
(J:81330)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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This allele is refered to as Tag-TCR2 by the authors. Tag-TCR2 animals carry multiple copies of both Tcra and Tcrb constructs integrated into the same locus.
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| Original: |
J:81330 Forster I, et al., Limited capacity for tolerization of CD4+ T cells specific for a pancreatic beta cell neo-antigen. Immunity. 1995 Jun;2(6):573-85 |
| All: |
4 reference(s) |
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Analysis Tools
