Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pcsk4tm1Mbi
Name:	proprotein convertase subtilisin/kexin type 4; targeted mutation 1, Majambu Mbikay
MGI ID:	MGI:2665512
Synonyms:	Pcsk4-
Gene:	Pcsk4  Location: Chr10:80157117-80165332 bp, - strand  Genetic Position: Chr10, 39.72 cM
Alliance:	Pcsk4tm1Mbi page

Germline Transmission:	Earliest citation of germline transmission: J:41503
Parent Cell Line:	E14TG2a (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: A genomic fragment encompassing exons 3 through 6 was replaced with a cassette containing lacZ and neo. The deleted region encoded 2 of the 4 residues of the catalytic domain. Neither transcript nor protein was detected by Northern and Western blot analyses of homozygous mutant testes. (J:41503)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pcsk4 Mutation:	45 strains or lines available

Original:	J:41503 Mbikay M, et al., Impaired fertility in mice deficient for the testicular germ-cell protease PC4. Proc Natl Acad Sci U S A. 1997 Jun 24;94(13):6842-6
All:	6 reference(s)