Summary | Transgene origin | Transgene description | Expression | Recombinase activity | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Tg(Foxa3-cre)1Khk
Name:	transgene insertion 1, Klaus H Kaestner
MGI ID:	MGI:2664968
Synonyms:	Foxa3cre, Foxa3.cre, Foxa3Cre, Foxa3-Cre, Tg(Foxa3-cre)1Khk
Transgene:	Tg(Foxa3-cre)1Khk  Location: unknown
Alliance:	Tg(Foxa3-cre)1Khk page

Strain of Origin:

(DBA x C57BL/6)F1

Transgene Type:    Transgenic (Recombinase) Mutation:    Insertion   Tg(Foxa3-cre)1Khk expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note Not Specified Foxa3   Mutation details: The transgenic construct consists of a 170 kb fragment containing a modified Foxa3 locus in which exon 2 has been replaced with an IRES-cre cassette. Cre activity was first detected 8.5 dpc in the anterior intestinal portal, and later in the entire gut endoderm from stomach to colon. Efficient cre-mediated recombination was demonstrated in the stomach, liver, pancreas, and colon. (J:96332)

Activity:	Tissue activity of this recombinase allele
Driver:	Foxa3 (species not specified) Summary of all recombinase alleles driven by Foxa3. Comparative matrix view of recombinase activities

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

419 assay results 7 RNA-Seq or microarray experiment(s)

List all tumor models in MMHCdb carrying Tg(Foxa3-cre)1Khk

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:96332 Lee CS, et al., Foxa2 is required for the differentiation of pancreatic alpha-cells. Dev Biol. 2005 Feb 15;278(2):484-95
All:	37 reference(s)