Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Nanogtm1Yam
Name:	Nanog homeobox; targeted mutation 1, Shinya Yamanaka
MGI ID:	MGI:2664492
Synonyms:	Nanog-
Gene:	Nanog  Location: Chr6:122684448-122691592 bp, + strand  Genetic Position: Chr6, 57.8 cM, cytoband F2
Alliance:	Nanogtm1Yam page

Germline Transmission:	Earliest citation of germline transmission: J:83420
Parent Cell Line:	RF8 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 2 of the gene, which contains the homeodomain, was replaced with an IRES-Beta geo cassette. X-gal staining of preimplantation embryos detected beta-geo in the inner cell mass of blastocysts and the central portion of the morula but not in 32-cell stage embryos or earlier. (J:83420)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	6 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nanog Mutation:	46 strains or lines available

Original:	J:83420 Mitsui K, et al., The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. Cell. 2003 May 30;113(5):631-42
All:	8 reference(s)