Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Dio3tm1Stg
Name:	deiodinase, iodothyronine type III; targeted mutation 1, Donald St Germain
MGI ID:	MGI:2664293
Synonyms:	D3KO, -/-Dio3
Gene:	Dio3  Location: Chr12:110245664-110247531 bp, + strand  Genetic Position: Chr12, 60.56 cM, cytoband F1
Alliance:	Dio3tm1Stg page

Germline Transmission:	Earliest citation of germline transmission: J:80434
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutation:    Nucleotide substitutions   Mutation details: The insertion of a triple point mutation resulted in a missense mutation of the codon encoding the selenocysteine as well as of the codon immediately upstream. A floxed neo cassette was also incorporated into the untranslated region of the gene. Endogenous activity was undetected in the heads and bodies of homozygous mutant mice. The neomycin cassette was subsequently removed by crossing to a mouse carrying a cre transgene on the X chromosome. (J:80434, J:105434)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	92 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dio3 Mutation:	7 strains or lines available

Original:	J:80434 Hernandez A, et al., The gene locus encoding iodothyronine deiodinase type 3 (Dio3) is imprinted in the fetus and expresses antisense transcripts. Endocrinology. 2002 Nov;143(11):4483-6
All:	22 reference(s)