Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Hbbtm1Tow
Name:	hemoglobin beta chain complex; targeted mutation 1, Timothy Townes
MGI ID:	MGI:2664239
Synonyms:	Hbb0, Hbbth3, Hbbtm1Tmt
Gene:	Hbb  Location: unknown  Genetic Position: Chr7, Syntenic

Germline Transmission:	Earliest citation of germline transmission: J:29087
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Hbbtm1Tow involves 2 genes/genome features (Hbb-b2, Hbb-b1) View all   Mutation details: A genomic fragment encompassing all of Hbb-b1 and a 5' portion of Hbb-b2 was replaced with a neo cassette inserted by homologous recombination. (J:29087)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hbb Mutation:	47 strains or lines available

Original:	J:29087 Ciavatta DJ, et al., Mouse model of human beta zero thalassemia: targeted deletion of the mouse beta maj- and beta min-globin genes in embryonic stem cells. Proc Natl Acad Sci U S A. 1995 Sep 26;92(20):9259-63
All:	97 reference(s)