Summary | Transgene origin | Transgene description | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | Notes | References

Symbol:	Tg(NES-TVA)J12Ech
Name:	transgene insertion J12, Eric C Holland
MGI ID:	MGI:2663944
Synonyms:	Nestin:Tva, Ntv-1, N-tva, Ntv-a, Tg(NES-TVA)12Hev
Transgene:	Tg(NES-TVA)J12Ech  Location: unknown
Alliance:	Tg(NES-TVA)J12Ech page

Strain of Origin:

FVB/N

Transgene Type:    Transgenic (Inserted expressed sequence) Mutation:    Insertion   Mutation details: The transgene expresses TVA, the receptor for avian retrovirus ALV, subgroup A (ALV-A), from a quail cDNA under control of a modified human nestin promoter that includes the second-intron enhancer - which in adult mice directs expression specifically in early glial progenitor cells - and the herpes simplex virus thymidine kinase (HSV-TK) promoter. Cells presenting this receptor can be infected by replication-competent ALV splice acceptor (RCAS) vectors, permitting cell type specific expression of vector-borne genes. (J:52161)

View phenotypes and curated references for all genotypes (concatenated display).

List all tumor models in MMHCdb carrying Tg(NES-TVA)J12Ech

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available

Original:	J:52161 Holland EC, et al., A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice. Genes Dev. 1998 Dec 1;12(23):3675-85
All:	88 reference(s)