Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Elf3tm1Pjh
Name:	E74-like factor 3; targeted mutation 1, Paul J Hertzog
MGI ID:	MGI:2662485
Synonyms:	Elf3-
Gene:	Elf3  Location: Chr1:135181312-135186210 bp, - strand  Genetic Position: Chr1, 58.42 cM, cytoband F
Alliance:	Elf3tm1Pjh page

Germline Transmission:	Earliest citation of germline transmission: J:76344
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout, Reporter) Mutation:    Insertion   Mutation details: Exon 2 was disrupted by the insertion of a cassette containing lacZ and neo. An elongated transcript resulting from readthrough of the polyadenylation signal of the selection cassette was detected by Northern blot analysis of mutant mice. While protein analysis was not conducted, the allele was putatively null due to stop codons within the neo gene. (J:76344)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Elf3 Mutation:	38 strains or lines available

Original:	J:76344 Ng AY, et al., Inactivation of the transcription factor Elf3 in mice results in dysmorphogenesis and altered differentiation of intestinal epithelium. Gastroenterology. 2002 May;122(5):1455-66
All:	5 reference(s)