Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Fat1tm1Cfc
Name:	FAT atypical cadherin 1; targeted mutation 1, Charles ffrench-Constant
MGI ID:	MGI:2662293
Synonyms:	mFAT1-
Gene:	Fat1  Location: Chr8:45388484-45505294 bp, + strand  Genetic Position: Chr8, 24.81 cM
Alliance:	Fat1tm1Cfc page

Germline Transmission:	Earliest citation of germline transmission: J:83058
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129/Sv

Allele Type:    Targeted (Null/knockout, Reporter) Mutation:    Insertion   Mutation details: The gene was disrupted by insertion of an in-frame lacZ-neo cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by Western blot analysis of skin proteins. (J:83058)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fat1 Mutation:	208 strains or lines available

Original:	J:83058 Ciani L, et al., Mice Lacking the Giant Protocadherin mFAT1 Exhibit Renal Slit Junction Abnormalities and a Partially Penetrant Cyclopia and Anophthalmia Phenotype. Mol Cell Biol. 2003 May;23(10):3575-82
All:	5 reference(s)