Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Pdpntm1Mcws Name: podoplanin; targeted mutation 1, Mary C Williams MGI ID: MGI:2657021 Synonyms: Gp38tm1Mir, T1alpha- Gene: Pdpn  Location: Chr4:142994001-143026134 bp, - strand  Genetic Position: Chr4, 77.29 cM Alliance: Pdpntm1Mcws page

Lung abnormalities become apparent after E15.5 in Pdpntm1Mcws/Pdpntm1Mcws mice Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:82687
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The 5' UTR, exon 1, and a portion of intron 1 were replaced with a neomycin selection cassette inserted by homologous recombination. Neither transcript nor protein was detected in homozygous mutant mice by Northern and Western blot analyses of neonatal lung tissue. RT-PCR analysis confirmed the absence of transcript in homozygous mutant brain and kidney tissue. (J:82687)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	30 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pdpn Mutation:	28 strains or lines available

Original:	J:82687 Ramirez MI, et al., T1alpha, a lung type I cell differentiation gene, is required for normal lung cell proliferation and alveolus formation at birth. Dev Biol. 2003 Apr 1;256(1):61-72
All:	6 reference(s)