Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Camk2atm1Vyb
Name:	calcium/calmodulin-dependent protein kinase II alpha; targeted mutation 1, Vadim Y Bolshakov
MGI ID:	MGI:2655688
Synonyms:	falpha-CaMKII KO
Gene:	Camk2a  Location: Chr18:61058704-61121224 bp, + strand  Genetic Position: Chr18, 34.41 cM
Alliance:	Camk2atm1Vyb page

Germline Transmission:	Earliest citation of germline transmission: J:82744
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A loxP site was introduced into intron 1 and an frt/loxP-flanked neo cassette was introduced to intron 2 via homologous recombination. The neo cassette was removed by transient expression of flp recombinase in correctly targeted ES cells. Resulting mutant mice carry a floxed exon 2 allele. (J:82744)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Camk2a Mutation:	136 strains or lines available

Original:	J:82744 Hinds HL, et al., Essential function of alpha-calcium/calmodulin-dependent protein kinase II in neurotransmitter release at a glutamatergic central synapse. Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4275-80
All:	3 reference(s)