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Six1tm1Mair
Targeted Allele Detail
Summary
Symbol: Six1tm1Mair
Name: sine oculis-related homeobox 1; targeted mutation 1, Pascal Maire
MGI ID: MGI:2655195
Synonyms: Six1-, Six1lacZ
Gene: Six1  Location: Chr12:73088601-73093486 bp, - strand  Genetic Position: Chr12, 30.34 cM
Alliance: Six1tm1Mair page
Spectrum of abnormalities of great artery patterning in mice with null mutation of one or both copies of Six1tm1Mair and Eya1tm1Rilm

Show the 4 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:82459
Parent Cell Line:  MPI-II (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe N-terminal portion of the gene was deleted by replacement of exon 1 with a lacZ-PGK-neo cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by immunohistochemical analysis. (J:82459)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 358 assay results
3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 45 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Six1 Mutation:  18 strains or lines available
Notes
These ES cells were additionally targeted in J:98519 to create Six1Six4 double knockouts.
References
Original:  J:82459 Laclef C, et al., Altered myogenesis in Six1-deficient mice. Development. 2003 May;130(10):2239-52
All:  34 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory