Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Slc1a1tm1Wst
Name:	solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1; targeted mutation 1, Wilheim Stoffel
MGI ID:	MGI:2655190
Synonyms:	eaac-1 -, EAAC1-, EAAT3-
Gene:	Slc1a1  Location: Chr19:28812535-28891360 bp, + strand  Genetic Position: Chr19, 23.5 cM
Alliance:	Slc1a1tm1Wst page

Germline Transmission:	Earliest citation of germline transmission: J:41613
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A neomycin selection cassette was inserted into exon 1 by homologous recombination. Northern blot analysis demonstrated that no detectable mRNA was expressed from this allele. (J:41613)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc1a1 Mutation:	35 strains or lines available

Original:	J:41613 Peghini P, et al., Glutamate transporter EAAC-1-deficient mice develop dicarboxylic aminoaciduria and behavioral abnormalities but no neurodegeneration. EMBO J. 1997 Jul 1;16(13):3822-32
All:	39 reference(s)