About   Help   FAQ
Trp53bp1tm1Jc
Targeted Allele Detail
Summary
Symbol: Trp53bp1tm1Jc
Name: transformation related protein 53 binding protein 1; targeted mutation 1, Junjie Chen
MGI ID: MGI:2654201
Synonyms: 53BP1-, Trp53bp1delta
Gene: Trp53bp1  Location: Chr2:121023762-121101888 bp, - strand  Genetic Position: Chr2, 60.37 cM
Alliance: Trp53bp1tm1Jc page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:82512
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe gene was disrupted by replacement of an exon containing nucleotides 3777 - 4048 with a neomycin resistance cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by Western blot analysis using an antibody directed against the N-terminal portion of the protein. (J:82512)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Trp53bp1tm1Jc
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Trp53bp1 Mutation:  100 strains or lines available
References
Original:  J:82512 Ward IM, et al., p53 Binding protein 53BP1 is required for DNA damage responses and tumor suppression in mice. Mol Cell Biol. 2003 Apr;23(7):2556-63
All:  57 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory