Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Plcb2tm1Dwu
Name:	phospholipase C, beta 2; targeted mutation 1, Dianqing Wu
MGI ID:	MGI:2653348
Gene:	Plcb2  Location: Chr2:118537998-118558919 bp, - strand  Genetic Position: Chr2, 59.43 cM
Alliance:	Plcb2tm1Dwu page

Germline Transmission:	Earliest citation of germline transmission: J:41948
Parent Cell Line:	CJ7 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: Sequence encoding the X box was disrupted by the insertion of a neomycin selection cassette. Western blot analysis of spleen and thymus extracts showed an absence of protein. (J:41948)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

List all tumor models in MMHCdb carrying Plcb2tm1Dwu

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Plcb2 Mutation:	54 strains or lines available

Original:	J:41948 Jiang H, et al., Roles of phospholipase C beta2 in chemoattractant-elicited responses. Proc Natl Acad Sci U S A. 1997 Jul 22;94(15):7971-5
All:	19 reference(s)