Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	CryaaAey7
Name:	crystallin, alpha A; dominant cataract 7
MGI ID:	MGI:2653028
Synonyms:	Aey7
Gene:	Cryaa  Location: Chr17:31896905-31900704 bp, + strand  Genetic Position: Chr17, 17.09 cM, cytoband A3-B
Alliance:	CryaaAey7 page

Strain of Origin:

C3HeB/FeJ

Allele Type:    Chemically induced (ENU) Mutation:    Single point mutation   Mutation details: The mutation is a T-to-A substitution at position 371 of the mRNA, which corresponds to a region in exon 3. This is predicted to cause a valine to glutamic acid replacement at codon 124. (J:72928) Inheritance:    Dominant

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cryaa Mutation:	14 strains or lines available

Original:	J:72928 Graw J, et al., Characterization of a new, dominant V124E mutation in the mouse alphaA-crystallin-encoding gene. Invest Ophthalmol Vis Sci. 2001 Nov;42(12):2909-15
All:	2 reference(s)