Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Insrrtm1Dac
Name:	insulin receptor-related receptor; targeted mutation 1, Domenico Accili
MGI ID:	MGI:2653019
Synonyms:	Irr-
Gene:	Insrr  Location: Chr3:87704258-87723408 bp, + strand  Genetic Position: Chr3, 38.7 cM
Alliance:	Insrrtm1Dac page

Germline Transmission:	Earliest citation of germline transmission: J:70602
Parent Cell Line:	CJ7 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: The gene was disrupted by insertion of a PGK-neo cassette into exon 3 via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by RT-PCR analysis of kidney RNA. (J:70602)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Insrr Mutation:	62 strains or lines available

Original:	J:70602 Kitamura T, et al., Preserved pancreatic beta-cell development and function in mice lacking the insulin receptor-related receptor. Mol Cell Biol. 2001 Aug;21(16):5624-30
All:	3 reference(s)