Tg(APOA4)8018Feb
Transgene Detail
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| Symbol: |
Tg(APOA4)8018Feb |
| Name: |
transgene insertion 8018, Francisco E Baralle |
| MGI ID: |
MGI:2652473 |
| Transgene: |
Tg(APOA4)8018Feb Location: unknown
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| Alliance: |
Tg(APOA4)8018Feb page
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| Strain of Origin: |
C57BL/6 x CBA
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(APOA4)8018Feb expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
APOA4 (337) |
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Mutation details: The transgene construct comprises the human APOA4 gene with ~7 kb of 5'- and 6 kb of 3'- flanking genomic DNA. This transgenic line was estimated by densitrometric Southern blot analysis to carry ~9 copies of the construct. Human APOA4 protein was detected in plasma of these mice at ~11 times the level in human plasma. Like the endogenous transcript, transgene-derived human Apoa4 mRNA was present at significant levels in liver and at much higher levels in intestine.
(J:82359)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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Nine copies of the transgene inserted into the genome.
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| Original: |
J:82359 Baralle M, et al., Regulation of the human apolipoprotein AIV gene expression in transgenic mice. FEBS Lett. 1999 Feb 19;445(1):45-52 |
| All: |
1 reference(s) |
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Analysis Tools
