Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Six3tm1Gco
Name:	sine oculis-related homeobox 3; targeted mutation 1, Guillermo Oliver
MGI ID:	MGI:2450901
Synonyms:	Six3-
Gene:	Six3  Location: Chr17:85921036-85933619 bp, + strand  Genetic Position: Chr17, 55.42 cM
Alliance:	Six3tm1Gco page

Germline Transmission:	Earliest citation of germline transmission: J:81797
Parent Cell Line:	W9.5/W95 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout, Reporter) Mutation:    Insertion   Mutation details: The endogenous allele was disrupted by the in frame insertion of Beta-gal and neo 22 codons downstream of the start codon. An absence of protein in homozygous mutant mice was indicated by immunofluorescence. (J:81797)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 assay results
In Structures Affected by this Mutation:	9 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Six3 Mutation:	13 strains or lines available

Original:	J:81797 Lagutin OV, et al., Six3 repression of Wnt signaling in the anterior neuroectoderm is essential for vertebrate forebrain development. Genes Dev. 2003 Feb 1;17(3):368-79
All:	6 reference(s)