Tph1tm1Bdr
Targeted Allele Detail
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| Symbol: |
Tph1tm1Bdr |
| Name: |
tryptophan hydroxylase 1; targeted mutation 1, Michael Bader |
| MGI ID: |
MGI:2450301 |
| Synonyms: |
Tph-, Tph1- |
| Gene: |
Tph1 Location: Chr7:46294065-46321961 bp, - strand Genetic Position: Chr7, 30.43 cM
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| Alliance: |
Tph1tm1Bdr page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:81435
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
Not Specified
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutation: |
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Insertion
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Mutation details: An isoform specific disruption of the endogenous allele was achieved by the insertion of neomycin and thymidine kinase cassettes via homologous recombination. The disruption putatively resulted in functional ablation in the peripheral tissues. The endogenous allele encodes the rate-limiting enzyme for serotonin synthesis, and while serotonin was detected at normal levels in the brain, it was absent in the periphery, with the exception of low levels (4% of wild-type) detected in the duodenum.
(J:81435)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Tph1 Mutation: |
39 strains or lines available
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| Original: |
J:81435 Walther DJ, et al., Synthesis of serotonin by a second tryptophan hydroxylase isoform. Science. 2003 Jan 3;299(5603):76 |
| All: |
35 reference(s) |
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Analysis Tools
