Summary | Transgene origin | Transgene description | Expression | Recombinase activity | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | Notes | References

Symbol:	Tg(KRT14-cre)1Amc
Name:	transgene insertion 1, Andrew P McMahon
MGI ID:	MGI:2445832
Synonyms:	K14cre, K14 cre, K14-cre, Krt14Cre
Transgene:	Tg(KRT14-cre)1Amc  Location: unknown
Alliance:	Tg(KRT14-cre)1Amc page

Strain of Origin:

(C57BL/6 x CBA)F1

Transgene Type:    Transgenic (Recombinase) Mutation:    Insertion   Tg(KRT14-cre)1Amc expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Homolog in Mouse Note human KRT14 (3861) Krt14  (MGI:96688)   Mutation details: The transgene is composed of a cre recombinase gene under the control of a human keratin 14 promoter. The human KRT14 promoter directs transgene expression in hair and skin. The transgene also contains a human growth hormone sequence and polyadenylation signal. When crossed to a transgenic reporter line, beta-galactosidase activity was detected in the oral ectoderm at 11.75 dpc, and at 14.5 dpc activity is detected in the skin and throughout the dental epithelium. (J:65294, J:243633)

Activity:	Tissue activity of this recombinase allele
Driver:	KRT14 (human) Summary of all recombinase alleles driven by KRT14. Comparative matrix view of recombinase activities Alliance human KRT14 gene page

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

223 assay results 24 RNA-Seq or microarray experiment(s)

List all tumor models in MMHCdb carrying Tg(KRT14-cre)1Amc

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available

Original:	J:65294 Dassule HR, et al., Sonic hedgehog regulates growth and morphogenesis of the tooth. Development. 2000 Nov;127(22):4775-85
All:	370 reference(s)