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Pcyox1tm1Sgy
Targeted Allele Detail
Summary
Symbol: Pcyox1tm1Sgy
Name: prenylcysteine oxidase 1; targeted mutation 1, Stephen G Young
MGI ID: MGI:2449567
Synonyms: Pcly -, Pcyox1tm1Abe
Gene: Pcyox1  Location: Chr6:86362988-86374132 bp, - strand  Genetic Position: Chr6, 37.69 cM
Alliance: Pcyox1tm1Sgy page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:79474
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP-flanked neomycin selection cassette replaced exon 6, which encodes the carboxy-terminus of the protein. Northern blot analysis on RNA derived from various tissues of homozygous mice demonstrated that truncated transcripts were expressed from this allele. (J:79474)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pcyox1 Mutation:  26 strains or lines available
References
Original:  J:79474 Beigneux A, et al., Prenylcysteine lyase deficiency in mice results in the accumulation of farnesylcysteine and geranylgeranylcysteine in brain and liver. J Biol Chem. 2002 Oct 11;277(41):38358-63
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory