Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Nfiatm1Rmg Name: nuclear factor I/A; targeted mutation 1, Richard M Gronostajski MGI ID: MGI:2449024 Synonyms: Nfia- Gene: Nfia  Location: Chr4:97660971-98007111 bp, + strand  Genetic Position: Chr4, 45.52 cM, cytoband C4-C6 Alliance: Nfiatm1Rmg page

Hydrocephalus in Nfiatm1Rmg/Nfiatm1Rmg mice Show the 8 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:58137
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The gene was disrupted by replacement of 219 bp of exon 2 and the 3' splice acceptor with a PGK-neo cassette via homologous recombination. The mutant allele generates a fusion between exons 1 and 3 resulting in an out-of-frame transcript with a nonsense codon in exon 3. The mutant allele was verified by RT-PCR and sequence analysis. (J:58137)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	3 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	11 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nfia Mutation:	28 strains or lines available

Original:	J:58137 das Neves L, et al., Disruption of the murine nuclear factor I-A gene (Nfia) results in perinatal lethality, hydrocephalus, and agenesis of the corpus callosum. Proc Natl Acad Sci U S A. 1999 Oct 12;96(21):11946-51
All:	23 reference(s)