Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Sirt1tm1Mcby
Name:	sirtuin 1; targeted mutation 1, Michael W McBurney
MGI ID:	MGI:2448246
Synonyms:	Sir2-, sir2alpha null, SIRT1-, Sirt1 KO
Gene:	Sirt1  Location: Chr10:63154784-63174814 bp, - strand  Genetic Position: Chr10, 32.57 cM
Alliance:	Sirt1tm1Mcby page

Germline Transmission:	Earliest citation of germline transmission: J:81010
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The gene was disrupted by replacement of exons 5 and 6, which encode a large portion of the catalytic domain, with a hygromycin resistance cassette via homologous recombination. Northern blot analysis of RNA from homozygous mutant E12.5 embryos and adult tissues did not detect gene expression. (J:81010)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	7 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	21 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Sirt1 Mutation:	78 strains or lines available

Original:	J:81010 McBurney MW, et al., The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis. Mol Cell Biol. 2003 Jan;23(1):38-54
All:	72 reference(s)