Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Sall2tm1Ryn
Name:	spalt like transcription factor 2; targeted mutation 1, Ryuichi Nishinakamura
MGI ID:	MGI:2448237
Gene:	Sall2  Location: Chr14:52548634-52566127 bp, - strand  Genetic Position: Chr14, 26.89 cM, cytoband B-C1
Alliance:	Sall2tm1Ryn page

Germline Transmission:	Earliest citation of germline transmission: J:81008
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The gene was disrupted by replacement of a portion of exon 2 encoding 5 N-terminal zinc fingers with a neomycin resistance cassette via homologous recombination. Northern blot analysis of mRNA from homozygous mutant mice did not detect wild-type transcript. However, hybridization with a C-terminal probe revealed a shortened transcript containing the neo cassette. The mutant transcript contains multiple stop codons as assessed by sequence analysis and most likely does not encode a functional protein. (J:81008)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

13 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sall2 Mutation:	51 strains or lines available

Original:	J:81008 Sato A, et al., Zinc finger protein sall2 is not essential for embryonic and kidney development. Mol Cell Biol. 2003 Jan;23(1):62-9
All:	3 reference(s)