Summary | Mutation origin | Mutation description | Tumor data | Find Mice (IMSR) | References

Symbol:	Gt(ROSA)26Sortm2Dym
Name:	gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Susan Dymecki
MGI ID:	MGI:2447934
Synonyms:	Gt(ROSA)26Sortm1(ALPP)Dym, R26:FRAP, R26::FRAP, R26FRAPki
Gene:	Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance:	Gt(ROSA)26Sortm2Dym page

Germline Transmission:	Earliest citation of germline transmission: J:72406
Parent Cell Line:	AK7 (ES Cell)
Strain of Origin:	129S4/SvJaeSor

Allele Type:    Targeted (Reporter) Mutation:    Insertion   Mutation details: An Flp-dependent alkaline phosphatase reporter locus was generated by inserting a construct containing an frt-flanked PGK-neo gene followed by sequence encoding human ALPP. The inserted construct contained a splice acceptor site at the 5' end. In addition to transcriptional and translational stop signals in the frt-flanked region, the frt-flanked neo cassette was inserted immediately downstream of the ALPP start codon to ensure a lack of ALPP activity in the absence of Flp-mediated excision. (J:72406)

List all tumor models in MMHCdb carrying Gt(ROSA)26Sortm2Dym

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:	942 strains or lines available

Original:	J:72406 Awatramani R, et al., An Flp indicator mouse expressing alkaline phosphatase from the ROSA26 locus. Nat Genet. 2001 Nov;29(3):257-9
All:	6 reference(s)