Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Tns1tm1Efu Name: tensin 1; targeted mutation 1, Elaine Fuchs MGI ID: MGI:2447792 Synonyms: Tensn -/- Gene: Tns1  Location: Chr1:73949390-74163608 bp, - strand  Genetic Position: Chr1, 38.17 cM Alliance: Tns1tm1Efu page

Kidney abnormalities in Tns1tm1Efu/Tns1tm1Efu mice Show the 2 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:39202
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A region encoding amino acids 110-180 was replaced with a neomycin cassette. This replacement disrupts both of the transcripts encoded by this gene. Immunoblot analysis on extracts of skin fibroblasts derived from homozygous mice confirmed that no detectable protein is made from this allele. (J:39202)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tns1 Mutation:	84 strains or lines available

Original:	J:39202 Lo SH, et al., Progressive kidney degeneration in mice lacking tensin. J Cell Biol. 1997 Mar 24;136(6):1349-61
All:	5 reference(s)