Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Foxo1tm1Whb
Name:	forkhead box O1; targeted mutation 1, William H Biggs III
MGI ID:	MGI:2447732
Synonyms:	Foxo1-, FoxO1+
Gene:	Foxo1  Location: Chr3:52175758-52257530 bp, + strand  Genetic Position: Chr3, 23.19 cM
Alliance:	Foxo1tm1Whb page

Germline Transmission:	Earliest citation of germline transmission: J:79560
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: The endogenous locus was disrupted by a beta-geo cassette inserted immediately downstream of the start codon in exon 1 by homologous recombination. The deleted region included the coding region of exon 1 and approximately 3 kb of intronic sequnence. Transcript was undetected by RT-PCR analysis of homozygous mutant embryos. (J:79560)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Foxo1 Mutation:	31 strains or lines available

Original:	J:79560 Nakae J, et al., Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1. Nat Genet. 2002 Oct;32(2):245-53
All:	11 reference(s)