Summary | Transgene origin | Transgene description | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Tg(APP)8.9Btla
Name:	transgene insertion 8.9, Bruce Lamb
MGI ID:	MGI:2447591
Synonyms:	APPYAC, hABetaPP, hAPP-YAC, Py8.9, Tg(APP)C9.24Jgh
Transgene:	Tg(APP)8.9Btla  Location: unknown
Alliance:	Tg(APP)8.9Btla page

Germline Transmission:	Earliest citation of germline transmission: J:80947
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence) Mutation:    Insertion   Tg(APP)8.9Btla expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human APP (351) App  (MGI:88059)   Mutation details: A 650 kb YAC containing the entire human APP gene and 350 kb of flanking sequence was randomly integerated into ES cells. Southern blot analysis confirmed that construct rearrangement did not occur and that the animals carried a single copy of the intact transgene. Quantitative RT-PCR analysis of transgenic and wild-type mice revealed that the levels of transgenic human alternate transcripts corresponded with those of the endogenous alternative transcripts. The human APP promoter drives expression in the brain, heart, kidney and testes. (J:80947)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:80947 Lamb BT, et al., Introduction and expression of the 400 kilobase amyloid precursor protein gene in transgenic mice [corrected]. Nat Genet. 1993 Sep;5(1):22-30
All:	16 reference(s)