Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Il3tm1Glli
Name:	interleukin 3; targeted mutation 1, Stephen J Galli
MGI ID:	MGI:2446538
Synonyms:	Il-3-
Gene:	Il3  Location: Chr11:54156129-54158103 bp, - strand  Genetic Position: Chr11, 32.13 cM, cytoband B1
Alliance:	Il3tm1Glli page

Germline Transmission:	Earliest citation of germline transmission: J:80640
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A 5' portion of exon 3 was replaced by the insertion of a neomycin selection cassette. The absence of normal protein was indicated by ELISA and proliferative studies using a myeloid cell line. (J:80640)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

List all tumor models in MMHCdb carrying Il3tm1Glli

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Il3 Mutation:	29 strains or lines available

Original:	J:80640 Mach N, et al., Involvement of interleukin-3 in delayed-type hypersensitivity. Blood. 1998 Feb 1;91(3):778-83
All:	29 reference(s)