Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gabrr1tm1Nsp
Name:	gamma-aminobutyric acid type A receptor subunit rho 1; targeted mutation 1, Neal S Peachy
MGI ID:	MGI:2446461
Synonyms:	GABAc rho1 null, Gabrr1tm1Mmc
Gene:	Gabrr1  Location: Chr4:33132556-33163606 bp, + strand  Genetic Position: Chr4, 14.68 cM
Alliance:	Gabrr1tm1Nsp page

Germline Transmission:	Earliest citation of germline transmission: J:76682
Parent Cell Line:	HM-1 (ES Cell)
Strain of Origin:	129P2/OlaHsd-Hprt1b-m3

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin selection cassette replaced exons 2-9 by homologous recombination. Immunohistochemistry analysis on retina demonstrated that ablation of this subunit resulted in the absence of all GABA-C immunoreactivity. (J:76682)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gabrr1 Mutation:	34 strains or lines available

Original:	J:76682 McCall MA, et al., Elimination of the rho1 subunit abolishes GABA(C) receptor expression and alters visual processing in the mouse retina. J Neurosci. 2002 May 15;22(10):4163-74
All:	9 reference(s)