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Tg(Camk2a-cre/ERT2)1Casa
Transgene Detail
Summary
Symbol: Tg(Camk2a-cre/ERT2)1Casa
Name: transgene insertion 1, Emilio Casanova
MGI ID: MGI:2445680
Synonyms: ERiCreER, Tg(Camk2a-cre/Esr1)1Casa
Transgene: Tg(Camk2a-cre/ERT2)1Casa  Location: unknown  
Alliance: Tg(Camk2a-cre/ERT2)1Casa page
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Tg(Camk2a-cre/ERT2)1Casa expression driven by 1 gene
 
Mutation detailsThe transgene consists of a BAC vector carrying a tamoxifen-inducible cre recombinase gene under the control of Camk2a regulatory elements, an eGFP cassette, and a bovine growth hormone polyadenylation signal. The cre recombinase gene is flanked by 2 ERT2 ligand binding domains. The Camk2a promoter targets transgene expression to the brain. High expression was observed in the hippocampus and cortex, intermediate expression was observed in the striatum, thalamus, and hypothalamus, and no detectable expression was observed in the cerebellum. This transgenic line carries 8 copies of the integrated construct. (J:80195)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Camk2a (species not specified)
Summary of all recombinase alleles driven by Camk2a.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:80195 Casanova E, et al., ER-based double icre fusion protein allows partial recombination in forebrain. Genesis. 2002 Nov;34(3):208-14
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory