Ncoa6tm1Jxu
Targeted Allele Detail
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| Symbol: |
Ncoa6tm1Jxu |
| Name: |
nuclear receptor coactivator 6; targeted mutation 1, Jianming Xu |
| MGI ID: |
MGI:2445463 |
| Synonyms: |
AIB3- |
| Gene: |
Ncoa6 Location: Chr2:155232585-155315741 bp, - strand Genetic Position: Chr2, 77.26 cM, cytoband H2
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| Alliance: |
Ncoa6tm1Jxu page
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Small size and heart abnormalities in Ncoa6tm1Jxu/Ncoa6tm1Jxu embryos
Show the 2 phenotype image(s) involving this allele.
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| Germline Transmission: |
Earliest citation of germline transmission:
J:80175
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| Parent Cell Line: |
TC1/TC-1 (ES Cell)
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| Strain of Origin: |
129S6/SvEvTac
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| Allele Type: |
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Targeted (Null/knockout, Reporter) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A 21.4 kb sequence fragment containing exons 4, 5, and 6 and encoding amino acids 171 through 895 was replaced by a cassette containing lacZ and neo. While the translation of a truncated amino terminal peptide was anticipated, no normal protein was detected in homozygous mutant mice using a carboxyl terminal antibody. The predicted truncated peptide putatively lacked domains necessary for interactions with transcription factors, DNA dependent protein kinases, and other protein complexes.
(J:80175)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Ncoa6 Mutation: |
100 strains or lines available
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| Original: |
J:80175 Kuang SQ, et al., Deletion of the Cancer-amplified Coactivator AIB3 Results in Defective Placentation and Embryonic Lethality. J Biol Chem. 2002 Nov 22;277(47):45356-60 |
| All: |
5 reference(s) |
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Analysis Tools
