Summary | Mutation origin | Mutation description | Expression | Recombinase activity | Phenotypes | Find Mice (IMSR) | References

Symbol:	Taglntm1(cre/ERT2)Feil
Name:	transgelin; targeted mutation 1, Robert Feil
MGI ID:	MGI:2389040
Synonyms:	SM22alphaCew-ERT2, SM-Cre ERT2(ki), SM-CreERT2(ki), SM-CreERT2(ki), Taglntm1(cre/ESR1)Feil
Gene:	Tagln  Location: Chr9:45840926-45847356 bp, - strand  Genetic Position: Chr9, 25.36 cM
Alliance:	Taglntm1(cre/ERT2)Feil page

Germline Transmission:	Earliest citation of germline transmission: J:69325
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Taglntm1(cre/ERT2)Feil expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Tagln (MGI:106012)   Mutation details: An allele encoding a tissue specific and ligand dependent recombinase was generated by inserting cre recombinase/modified estrogen receptor (ESR1) fusion sequence into the endogenous allele. The ESR1 sequence contained engineered missense mutations at positions 400, 543, 540 which substituted the ability to bind the endogenous ligand with the ability to bind tamoxifen (J:79835). Histochemical analysis of mutant mice treated with tamoxifen showed expression of cre in smooth muscle tissue. (J:69325)

Activity:	Tissue activity of this recombinase allele
Driver:	Tagln (mouse) Summary of all recombinase alleles driven by Tagln. Comparative matrix view of recombinase activities Alliance mouse Tagln gene page

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

15 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tagln Mutation:	26 strains or lines available

Original:	J:69325 Kuhbandner S, et al., Temporally controlled somatic mutagenesis in smooth muscle. Genesis. 2000 Sep;28(1):15-22
All:	36 reference(s)