Summary | Transgene origin | Transgene description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tg(Myh6-ADRBK1)27Wjk
Name:	transgene insertion 27, Walter Koch
MGI ID:	MGI:2389030
Synonyms:	BetaARKct, TG betaARKct, Tg(minBARKct)27Wjk, TGMini27
Transgene:	Tg(Myh6-ADRBK1)27Wjk  Location: unknown
Alliance:	Tg(Myh6-ADRBK1)27Wjk page

Strain of Origin:

(C57BL/6 x SJL)F1

Transgene Type:    Transgenic (Inserted expressed sequence) Mutation:    Insertion   Tg(Myh6-ADRBK1)27Wjk expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human GRK2 (156) Grk2  (MGI:87940)   Tg(Myh6-ADRBK1)27Wjk expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note mouse Myh6 (MGI:97255)   Mutation details: Sequence encoding the carboxyl terminus of the bovine adrenergic receptor kinase, beta 1 (ADRBK1) (residues 495 through 689) was ligated to a 5.5 kb fragment of the murine adult myosin, heavy polypeptide 6, cardiac muscle, alpha (Myh6) promoter. The resultant 194 residue carboxyl terminal peptide was detected by Western blot analysis and inhibits endogenous beta-adrenergic receptor kinase-1 by blocking beta-adrenergic receptor desensitization. The Myh6 promoter drives expression in myocardial tissue. (J:37034)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:37034 Koch WJ, et al., Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor. Science. 1995 Jun 2;268(5215):1350-3
All:	15 reference(s)